The White House issued an executive order on November 24, 2025 launching the “Genesis Mission,” a US Department of Energy-led national initiative to accelerate scientific discovery using advanced Artificial Intelligence. The Mission aims to unify high-performance computing, secure cloud-based Artificial Intelligence environments, and federal scientific datasets into an American Science and Security Platform that will underpin scientific foundation models, Artificial Intelligence agents, and automated research and manufacturing systems across priority technology domains. The assistant to the president for science and technology will provide overall leadership and coordinate across federal agencies through the National Science and Technology Council.
The executive order establishes a set of binding implementation milestones to drive near-term activity. Within 60 days: DOE must identify at least 20 national science and technology challenges with high potential for Artificial Intelligence-enabled breakthroughs, including nuclear fission and fusion energy, biotechnology, advanced manufacturing, critical materials, semiconductors, and quantum information science. Within 90 days: DOE must inventory all available federal and partner computing, storage, and networking resources suitable for the Mission, including DOE supercomputers and secure commercial cloud environments, and identify needed infrastructure upgrades or partnerships. Within 120 days: DOE must identify initial datasets and model assets to be integrated into the Platform and develop a plan for incorporating additional datasets from agencies, federally funded research, academia, and approved private partners, subject to classification, privacy, export-control, and IP requirements. Within 240 days: DOE must assess national laboratory capabilities related to robotic laboratories, autonomous experimentation, and Artificial Intelligence-directed manufacturing. Within 270 days: DOE must seek to demonstrate an initial operating capability of the Platform for at least one identified national science or technology challenge. Within 1 year and annually thereafter: DOE must report to the US president on the Platform’s operational status, scientific achievements, public-private partnerships, and any authorities or resources needed to achieve Mission objectives.
The order signals clear priorities for Artificial Intelligence developers, cloud service providers, semiconductor and hardware companies, and data-center operators by calling for integration of DOE supercomputers with secure cloud-based computing environments and by promoting high-density Artificial Intelligence training and advanced networking hardware. Research institutions and consortia will face new data controls for sensitive categories and potential effects on grant eligibility and collaboration frameworks. Vendors of identity and access management, dataset-level security, supply chain assurance, and cloud security tooling may see increased demand as the Mission emphasizes verifiable compliance with federal cyber baselines. DOE is directed to create standardized collaboration arrangements, including cooperative research and development agreements, data-use and model-sharing agreements, and clear intellectual property and commercialization policies. In-house counsel should evaluate data use agreements, Federal Acquisition Regulation obligations, cybersecurity clauses, export control restrictions, foreign national access limits, indemnities and liability for model sharing, and evolving certification or audit requirements as DOE develops governance frameworks. The Genesis Mission could materially expand demand for high-performance Artificial Intelligence and reshape secure large-model training depending on appropriations, interagency alignment, and DOE’s detailed frameworks.
