How to run large language models locally and the evolution of three-parent babies

Researchers have made it possible to run large language models on laptops, while advances in DNA have enabled three-parent babies—highlighting technology´s impact on privacy and reproduction.

Recent advancements in artificial intelligence have broken down the barriers for enthusiasts looking to run large language models on personal devices. Initially, meaningful use of these powerful models demanded specialized hardware, typically GPUs and cloud access, making them largely inaccessible to mainstream users. Now, thanks to the concerted efforts of researchers, the models have been streamlined and optimized for efficiency, making it feasible for people to deploy these tools directly on a standard laptop or even a smartphone. This democratization fosters privacy, empowers individuals to bypass reliance on major LLM providers, and appeals to hobbyists eager to experiment with language technology independently.

The newsletter also chronicles the nuanced journey of procedures leading to ´three-parent babies.´ Reports indicate eight infants have been born in the UK through an experimental IVF technique that incorporates DNA from three individuals, aimed at preventing the inheritance of mitochondrial diseases. While the United Kingdom´s new arrivals made headlines, the practice has historical precedent, with various international teams pursuing similar methods over the past decade. The approach remains contentious, sparking ethical debate and regulatory scrutiny, yet it offers hope for families facing the risk of hereditary mitochondrial disorders.

Elsewhere in the newsletter, influential stories capture the current pulse of technology. OpenAI has announced its ChatGPT Agent, which automates digital tasks through a unique ´virtual computer,´ though it still faces efficiency hurdles. The White House is preparing directives to bar companies deemed to have ´liberal bias´ in their artificial intelligence models from federal contracts, raising questions about the feasibility of genuinely unbiased language models. Legal, ethical, and privacy issues surface in stories about Russia´s new laws targeting online searches, Meta´s settlement over privacy violations, and the expanding capabilities of facial recognition tools. Biotech news highlights a breakthrough in genetically modified chestnut trees, offering a potential boost to ecological restoration. Lighter notes, from stained glass art to the resurgence of flip phones, round out a comprehensive look at the ways technology intersects with daily life, comfort, and profound scientific progress.

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